| ID | JOS-toxsci-kfx058 |
| 著者：名前 | |
| 著者：別形式 | Kawabata, Kohei / Matsuzaki, Hirokazu / Nukui, Sahoko / Okazaki, Mari / Sakai, Ayako / Kawashima, Yoichi / Kudo, Naomi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 |
| 著者：所属(別形式） | Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, School of Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology |
| 著者版フラグ | author |
| 出版地 | Oxford |
| 出版者 | Oxford University Press |
| NCID | AA12038389 |
| 冊子ISSN | 10966080 |
| 電子ISSN | 10960929 |
| 掲載誌名 | |
| 巻 | 157 |
| 号 | 2 |
| 刊行年月 | 2017-06 |
| 開始ページ | 421 |
| 終了ページ | 428 |
| コンテンツ作成日 | 2017-06-01 |
| コンテンツ登録日 | 2018-06-13 |
| 識別番号：DOI | info:doi/10.1093/toxsci/kfx058 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 28402547 |
| 抄録 | The brain level of perfluorododecanoic acid (PFDoA) was compared with those of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in rats 9 days after a single oral dose (50 mg/kg). The PFDoA level in the brain was 44.0 ± 2.0 µg/g, which was higher than that in the serum (24.4 ± 1.0 µg/ml). In contrast, the concentrations of PFOA and PFDA in the brain were low (<0.8 and 4.7 ± 0.4 µg/g, respectively), and less than one-tenth of those in the serum. Next, to investigate the effects on brain function, the cognitive function alterations of PFOA, PFDA, and PFDoA were estimated by the novel object recognition test 5-6 days after dosing. A significant decrease in the discrimination index was observed in PFDoA-treated rats while no significant alteration was observed in PFDA- and PFOA-treated rats. The effects of PFDoA were further assessed by other behavioral tests. PFDoA-associated alteration was observed in the elevated-plus maze test, but not in the Y-maze test, open-field test, and forced swim test. A decrease in the discrimination index of the novel object recognition test was dependent on the PFDoA dose and the PFDoA concentration in the brain. PFDoA concentration in the brain was 28.6 ± 2.6 µg/g 30 days after dosing, and a decrease in discrimination index was observed. Taken together, these results suggest that PFDoA distributes in the brain easier than PFOA and PFDA and causes cognitive deficit. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2018 Society of Toxicology |
| このアイテムを表示する：本文(pdf) |  ( 403.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
