城西大学機関リポジトリJURAFish oil and fenofibrate inhibit pancreatic islet hypertrophy, and improve glucose and lipid metabolic dysfuntions with different ways in diabetic KK mice.

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Fish oil and fenofibrate inhibit pancreatic islet hypertrophy, and improve glucose and lipid metabolic dysfuntions with different ways in diabetic KK mice.

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ID	JOS-j.orcp.2016.03.012
著者：名前	中里見, 真紀/金, 賢珠/荒井, 健/平子, 哲史/塩田, 清二/飯塚, 譲/櫻井, 晃司/松本, 明世
著者：別形式	Nakasatomi, Maki / Kim, Hyounju / Arai, Takeshi / Hirako, Satoshi / Shioda, Seiji / Iizuka, Yuzuru / Sakurai, Koji / Matsumoto, Akiyo
著者：カナ	ナカサトミ, マキ/キム, ヒョンジュ/アライ, タケシ/ヒラコ, サトシ/シオダ, セイジ/イイヅカ, ユズル/サクライ, コウジ/マツモト, アキヨ
著者：所属	城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 人間総合科学大学人間科学部健康栄養学科 / 星薬科大学薬学部先端生命科学研究所 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / University of Human Arts and Sciences, Department of Health and Nutrition / Hoshi University, School of Pharmacy and Pharmaceutical Sciences, Global Research Center for Innovative Life Science / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition
著者版フラグ	author
出版地	Amsterdam
出版者	Elsevier
NCID	AA12156024
電子ISSN	1871403X
掲載誌名	Obesity Research & Cllinical Practice
巻	12
号	1S1
刊行年月	2018
開始ページ	29
終了ページ	38
コンテンツ作成日	2015-12-18
コンテンツ修正日	2016-03-24
コンテンツ登録日	2018-05-24
識別番号：DOI	info:doi/10.1016/j.orcp.2016.03.012
識別番号：DOI（リンク）	https://doi.org/10.1016/j.orcp.2016.03.012
PubMed番号	27130153
抄録	We examined the effects of fish oil and fenofibrate (FF) on the pancreatic islet hypertrophy, and on the modification of glucose and lipid metabolic dysfunctions in KK mice with insulin resistance. The mice were fed one of four diets [25 en% lard/safflower oil (LSO), 25 en% fish oil (FO), or each of these diets plus 0.1 wt% FF (LSO/FF, FO/FF)] for 9 weeks. FO group and both FF groups had significantly lower final body and adipose tissue weights than LSO group. Pancreatic islet hypertrophy was observed only in LSO group but not in the other groups with fish oil or FF. And, it is likely that fish oil has a stronger therapeutic effect on islet hypertrophy. Plasma adiponectin level was significantly higher in FO group but not in both FF groups. Expression of hepatic lipogenic enzyme genes such as fatty acid synthase (FAS) and stearoyl-CoA desaturase-1 (SCD-1) was lower in FO groups with or without FF, whereas fatty acid oxidation-related mRNAs such as acyl-CoA oxidase (AOX) and uncoupling protein-2 (UCP-2) were more abundant in FF groups with or without fish oil.Our results suggest that both fish oil and FF improve pancreatic islet hypertrophy with the amelioration of insulin resistance. Fish oil enhances insulin sensitivity by increasing plasma adiponectin; however, the beneficial effect of FF on insulin resistance seems to be independent of the plasma adiponectin level. These results mean that improvement of glucose and lipid metabolic dysfuctions in diabetic KK mice are independently approached by fish oil and FF.
キーワード	Fish oil/Fenofibrate/Islet hypertrophy/Insulin resistance
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2016 Asia Oceania Association for the Study of Obesity
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